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What is considered high risk obstetrics? A high-risk pregnancy is one in which a woman and her fetus face a higher-than-normal chance of experiencing problems. These risks may be due to factors in the pregnancy itself, or they may stem from preexisting maternal medical conditions, such as cancer, diabetes, or lupus.\ What are three high-risk pregnancy? Gestational diabetes. Multiple gestation (pregnancy with more than one fetus, such as twins or triplets). Preeclampsia and eclampsia. Previous preterm labor or birth, or other complications with previous pregnancies.